Timothy Vyse has an established reputation as an international leader in the genetics of SLE. He determined the molecular basis of hereditary complement factor I deficiency. Subsequently he delineated the pathogenic role of the MHC and autoantibodies in the NZB model of SLE. Vyse established his own group to work on the genetics of human SLE. Using large collections from his own clinical practice and through extensive international collaborations, he has defined the multigenic nature of SLE through candidate gene, linkage and genome-wide association studies. The work in his laboratory was key to establishing that gene copy number variation is a cause of human SLE, one of the first associations between gene copy number variation and a common human disease.
Fellow
Back to directory listingProfessor Timothy Vyse FMedSci
Job Title
Professor of Molecular Medicine
Department
Department of Genetics and Molecular Medicine
Institution
King's College London
Year elected
2013
Interests
Specialitiesgenetics of systemic autoimmunity, impact of genetic variation on immune function
Section committee elected byCellular and developmental biology, microbiology and immunology, genetics
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