Fellow

Anne Bertolotti, Programme Leader at the MRC Laboratory of Molecular Biology, is leading research internationally into human neurodegenerative diseases. She has worked on huntingtin aggregation and the assembly of mutant superoxide dismutase (SOD) 1 showing that huntingtin aggregation is context-dependent. She uncovered the mechanisms by which SOD1 mutations generate aggregates and her work on the prion-like properties of assembled SOD1 was pioneering and influenced studies on other protein assemblies. Following on from her discovery of several factors that are part of the cell's response to the perturbation of proteasome degradation, Anne's most recent work has led to the identification of an evolutionarily conserved pathway that controls proteasome homeostasis.