Fellows' discussion dinner: Professor Sarah Tabrizi, `Gene silencing approaches for Huntington's disease'



00.00, Monday 10 October 2016

Fellows are invited to attend a discussion dinner at the Academy featuring a talk by Professor Sarah Tabrizi FMedSci, Professor of Clinical Neurology and Honorary Consultant Neurologist, University College London.

Attendance costs £60 per head which includes drinks and a three-course meal. Fellows may bring one non-Fellow guest.
 
Abstract:
Huntington’s disease (HD) is a devastating autosomal dominantly inherited neurodegenerative disease for which there is currently no effective disease modifying therapy. The genetic predictability of HD provides an opportunity for early therapeutic intervention many years before overt symptom onset and at a time when reversal or prevention of neural dysfunction may still be possible. As HD is monogenetic, fully penetrant, and characterised by a long premanifest phase, it is emerging as a potential model for studying therapeutic intervention in other neurodegenerative conditions such as Alzheimer’s or Parkinson’s disease where no preclinical diagnostic tests exist. Understanding of HD pathogenesis is evolving, and there are a number of candidate therapeutics with potential disease-modifying effects that are currently being tested. The talk will outline briefly insights into HD pathogenesis, new data to understand the neurobiology of the preclinical phase of neurodegeneration, neural compensation and plasticity in HD, and then give a detailed overview on exciting advances working towards HD gene silencing approaches in humans. 
 
For more information contact alison.rojo@acmedsci.ac.uk or book a place using the form below.

Key contacts


 
 
 
 
 
 
FB Twitter Instagram Youtube