Fellow

Professor Malcolm Dunlop is a bowel cancer surgeon and internationally recognised cancer genetics researcher.. He is Professor of Coloproctology in Edinburgh and has made a major contribution to our understanding of genetic instability in colorectal cancer, and the biological mechanism of asprin as a chemopreventive agent acting through NFkappaB signalling and apoptosis. His work has been influential in demonstrating the cancer risk associated with germline DNA mismatch repair gene mutations and has shown that genetic instability is found in the majority of young patients with colorectal cancer. His work on aspirin has ranged from demonstration of beneficial effects in mouse models through to identification of a novel pathway by which aspirin can cause apopotosis This work has the potential to guide preventative approaches and develop new therapeutic agents. He is a clinician and has established a truly multidisciplinary team to assemble an impressively large and exceptionally well characterised case-control cohort that is yielding important findings that will influence clinical service provision in screening as well as informing the direction of basic science research. Professor Dunlop contributes much more than his own clinical practice and research and is heavily involved in providing policy advice at a national level, including national guidelines for cancer surveillance for population groups at elevated risk that have now been adopted by the British Society of Gastroenterology amongst others. He is a leading light in academic surgery.