Fellow

Frank Reimann is Professor of Endocrine Signalling at the University of Cambridge. His expertise in electrophysiology and ion channel structure-function relations has contributed critically to our understanding of the gut-brain axis. Pioneering the use of fluorescently tagged transgenic mouse models and human intestinal organoids, he employs dynamic single-cell imaging, RNA-sequencing and electrophysiology to study the fundamental cell biology and neurocircuitry of the gut-brain-pancreatic axis in which hormones such as glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide convey nutrition-dependent signals to the brain and pancreas to modulate appetite and metabolism. These hormones underlie the new classes of once-weekly injectable diabetes and obesity drugs with their substantial beneficial cardiovascular profiles.