Fellow

Andrew McKenzie is MRC Senior Scientist at the MRC Laboratory of Molecular Biology. He has made major contributions to dissecting the role of cytokines in type-2 immune responses. His initial work highlighted the importance of IL-13 in type-2 immune responses that characterise allergy and asthma. He established a programme using transgenic mouse models to dissect type-2 cytokine network in helminth and asthma models. He made a major breakthrough in understanding the innate regulatory pathways that control type-2 responses by identifying and characterising the novel innate immuno-regulatory nuocyte. His successful use of chromosomal engineering has generated the first mouse model of the human myelodysplasia 5q- syndrome.