Professor Timothy Vyse FMedSci

Timothy Vyse has an established reputation as an international leader in the genetics of SLE. He determined the molecular basis of hereditary complement factor I deficiency. Subsequently he delineated the pathogenic role of the MHC and autoantibodies in the NZB model of SLE. Vyse established his own group to work on the genetics of human SLE. Using large collections from his own clinical practice and through extensive international collaborations, he has defined the multigenic nature of SLE through candidate gene, linkage and genome-wide association studies. The work in his laboratory was key to establishing that gene copy number variation is a cause of human SLE, one of the first associations between gene copy number variation and a common human disease.