Jennifer Nichols, Professor of Embryonic Pluripotency at the University of Edinburgh, collaborates with world-renowned experts in Mendelian disorders, developmental dysfunction and genome engineering. She continues to exploit her considerable background and expertise in early mammalian development using genetically engineered mouse models and stem cell lines. To interrogate early postimplantation human dysfunction, she derived a bank of 20 unique clonal human embryonic stem cell lines directly from supernumerary human preimplantation embryos donated from assisted conception programmes. These novel clonal human embryonic stem cell lines enable comparison of euploid and aneuploid differentiation from the same individual, providing an accessible resource for the community, and the on-going exploitation of human pluripotent stem cells in regenerative medicine.