Imre Berger is Professor of Biochemistry at the University of Bristol. He has made critical contributions to basic and medical science through the development of enabling technologies to produce important eukaryotic multiprotein complexes in the quality and quantity required for their structural and mechanistic study. His innovations have enabled the structure determination and mechanistic characterization of critical macromolecular complexes of immense biological and pharmacological importance. Combined with developments in single particle cryo-electron microscopy, the capacity to reconstitute macromolecular complexes of defined composition has revolutionised structural and molecular biology and broadened the scope of complexes that are now amenable to structure-based drug discovery.