George Vassiliiou, Professor of Haematological Medicine at the University of Cambridge, has an exceptional track record of discovery and translation in blood cancer research. His co-discovery of clonal haematopoiesis marked a paradigm shift in our understanding of age-related blood disorders and cancer evolution. The demonstration that the risk of developing acute myeloid leukaemia can be predicted years in advance via blood DNA analysis, and the subsequent development of MN-Predict for quantifying personal risk of myeloid neoplasms, has set new standards for precision medicine and cancer prevention. His work exemplifies extraordinary impact across discovery science, translational research, and clinical application, significantly advancing our ability to understand, detect, prevent, and treat myeloid malignancies.