Professor Antony Galione FRS FMedSci
Professor of Pharmacology
University of Oxford
Elected Fellow 2010
Ca2+ signalling mechanisms, intracellular messengers, ion channels, organelles, lysosomes, fluorescent imaging, fertilisation, stimulus-secretion coupling
Antony Galione is Professor of Pharmacology at the University of Oxford. He has pioneered the elucidation of novel signal transduction pathways regulating calcium signalling. Using pharmacological, biochemical and physiological approaches, he showed that these messengers and their signalling pathways control many fundamental cellular processes including synaptic plasticity, membrane excitability, excitation-contraction coupling, and both endocrine and exocrine secretory mechanisms. His discovery of a novel family of endo-lysosomal calcium channels, the two-pore channels, has revealed an entirely new signalling role for these organelles which may impact on lysosomal storages diseases and other trafficking pathologies.