Menna Clatworthy is Professor of Translational Immunology at the University of Cambridge. She discovered that the specific environment of the kidney shapes resident immune cell response, demonstrating how regional differences in interstitial salinity act to optimize macrophage position and antibacterial function, preventing ascending urinary tract infection. This led to a detailed exploration of the previously unknown, but remarkably precise and detailed, anatomical “zonation” of immune functionality in the kidney. Her clinical trials have highlighted the importance of regulatory B cells in transplant survival. |Her many discoveries have implications for our understanding of disease with significant impacts on patient care.|