Frank Nestle is an outstanding clinician scientist working in Dermatology at King’s College London. He has made major contributions to our understanding of the immune pathogenesis of inflammatory and neoplastic skin disease. His most impressive work has been on the pathogenesis and therapy of psoriasis. He has developed a highly informative experimental model of the human disease by transplanting human lesional and non-lesional skin onto immunocompromised mice. His work has been translated into defining key integrins as potential therapeutic targets and has also extended to the genetic analysis of disease susceptibility. In collaboration with geneticists at King’s he has defined the gene encoding the interleukin-23 receptor as one that confers protection and dissected its functional relevance for T helper 17 cytokine secretion.