Springboard round 9 awardees
Dr Beatriz Bano Otalora, University of Manchester, Understanding the contribution of early-life light environment to circadian clock function in adulthood
Dr David Beal, University of Kent, The Synthesis of Cytochrome bd Inhibitors for the Treatment of Bacterial Infections
Dr Richard Bethlehem, University of Cambridge, Using brain charts to stratify and monitor Alzheimer's and related dementias.
Dr Honor Bixby, University of Essex, Fine-scale assessment of child mortality improvements and inequalities in Ghanaian cities: where and who is being left behind?
Dr Marco Bocchio, University of Durham, Optogenetic investigation of the role of serotonin in neuroplasticity
Dr Carlo Breda, De Montfort University, Investigate the role of RAB39B in Parkinson's disease
Dr Emily Brookes, University of Southampton, Uncovering the epigenetic mechanisms shaping the brain after early life adversity
Dr Ian Cadby, University of Bristol, Uncovering mechanisms of host cell subversion by tick-borne Anaplasma
Dr Maria Victoria Chirou, University of Bath, Do lipid droplets promote aggressive medulloblastoma tumour growth and if, so, can we do anything about it?
Dr Andrew Davidson, University of Glasgow, Harnessing necrosis to enhance anti-tumourigenic cell death and inflammation
Dr Alexandra Davies, University of Manchester, Investigating the role of protein mislocalisation in rare neurodegenerative diseases
Dr Alison Dicker, University of Dundee, Understanding the role of prescribing patterns and comorbidities in driving respiratory microbial dysbiosis in bronchiectasis disease progression
Dr Thomas Edwards, Liverpool School of Tropical Medicine, Investigating the drivers of gene amplification mediated resistance to beta-lactamase inhibitor combinations
Dr Romy Froemer, University of Birmingham, Pointless effort? Dissecting mechanisms underlying motivational impairments
Dr Ryuichi Fukuda, King's College London, Molecular mechanism of cardiomyocyte dedifferentiation via TCF3
Dr Mattia Francesco Maria Gerli, University College London, Single cell-guided prenatal derivation of primary epithelial organoids from the human amniotic fluid to model fetal tissue development and congenital disease.
Dr Camilla Godlee, University of Cambridge, Host factors required for the membrane integration of bacterial virulence proteins during infection
Dr Luke Green, University of Sheffield, Unravelling sex-specific tetraspanin platforms during Neisseria gonorrhoeae infection
Dr Noemie Hamilton, University of York, Define the role of microglia in the pathology of leukodystrophies
Dr Ricci Hannah, King's College London, Non-invasive neural biomarkers for tracking the effects of anti-seizure medications
Dr Odile Harrison, University of Oxford, Towards an improved genomic representation of Neisseria gonorrhoeae in Africa - TIGRA
Dr Shivanand Hegde, Keele University, Investigating the interactions between gut bacteria and the arboviruses chikungunya virus and zika virus in the gut of mosquitoes
Dr Joanne Hobbs, University of St Andrews, Unravelling the Molecular Mechanisms Behind Prs-Mediated Antibiotic Tolerance
Dr Nathan Hodson, Manchester Metropolitan University, Exploring the (dys)regulation of the mTORC1-lysosomal axis in obesity-related skeletal muscle anabolic resistance
Dr Lisa Holbrook, University of Surrey, Determining how redox active thiol isomerases regulate GPCR signalling pathways
Dr Emilie Hollville, University of Aberdeen, Investigating the molecular basis of neuronal development regulated by the schizophrenia risk factor CUL9
Dr Laura Kudrna, University of Birmingham, Developing a culturally sensitive survey scale measure of the experience of meaningful work among healthcare staff
Dr Thomas Laver, University of Exeter, Uncovering the contribution of copy number variants to disorders of insulin secretion
Dr Jack Leslie, Newcastle University, Establishing cancer associated fibroblasts as immunotherapeutic targets in liver cancer
Dr Jennifer Maher, University of Bath, Novel Use of Neuromuscular Electrical Stimulation to Improve Glucose Control in Individuals with Spinal Cord Injury
Dr Yolanda Markaki, University of Leicester, Regulation of the X chromosome in pluripotency, development and disease
Dr Laura Martin-Sancho, Imperial College London, Evasion of human front-line defences as a determinant of Dengue-2 pathogenesis
Dr Alessandro Mongera, University College London, Metabolic control of tissue phase transitions
Dr Leticia Monin Aldama, Imperial College London, Understanding and rewiring gd TCR-epithelial interactions for gut-targeted immunotherapies.
Dr Sophie Morse, Imperial College London, Therapeutic Ultrasound to Delay Cognitive Decline
Dr Tom Nightingale, University of Birmingham, Non-invasive neuromodulation combined with upper-body exercise to optimise cardiovascular and immune outcomes in individuals with spinal cord injury
Dr Alejandro Paredes, Queen's University Belfast, Development of an oral formulation for the treatment of visceral leishmaniasis
Dr Alexandra Pike, University of York, Understanding the relationship between eating disorders, self-efficacy and control-seeking
Dr Juan Fernando Quintana, University of Manchester, Meningeal immunity as driver of brain pathology during chronic CNS infections
Dr Kim Robinson, University of York, Investigating the role of the inflammasome as a driver for inflammatory skin diseases
Dr Philipp Ruhnau, University of Central Lancashire, Improving communication between bilateral auditory cortex regions with transcranial alternating current stimulation
Dr David Rusling, University of Portsmouth, Triplex DNA: The next platform for oligonucleotide drug development
Dr Dylan Ryan, University of Cambridge, METABOMAC – Metabolic control of inflammatory macrophage function
Dr Maitreyi Shivkumar, De Montfort University, Development of pan-coronavirus antivirals by targeting host kinases.
Dr Joseph Sollini, University of Nottingham, Reversing the neural consequences of hearing-loss to restore hearing-in-noise sensitivity
Dr Matthew Sullivan, University of East Anglia, New roles for amino acid pathways in subverting metal stress in Streptococcus
Dr Karthic Swaminathan, University of Bradford, The Sweet Side of the Cancer: Role of sialylation in Melanoma Metastasis
Dr Rachel Tanner, University of Oxford, Exploring antibody correlates of protection from TB using an attenuated mycobacterial controlled human infection model
Dr Aidan Taylor, University of Reading, Integration of TraDIS into a continuous culture model of the human enteric pathogen Campylobacter jejuni
Dr Audrey Teh, St. George's University of London, Improving plant-expressed Immune Checkpoint Inhibitors for affordable cancer immunotherapy: impacts of Fc and glycan engineering
Dr Dorothy Tse, Edge Hill University, Translating a novel schema memory paradigm from animals to human to advance understanding of memory processes
Dr Fiona Whelan, University of Nottingham, Understanding microbe-pathogen interactions in a clinically relevant model of the cystic fibrosis lung
Dr Rémi Zallot, Manchester Metropolitan University, STEROSPRING: Characterising an Uncharted Lanosterol Catabolic Pathway in Non-Tuberculous Mycobacterial (NTM) Species
Dr Yanfeng Zhang, University of Exeter, Function and interaction of acetylcholine and dopamine systems in health and disease
Springboard round 8 awardees
Dr Neha Agrawal, University of Edinburgh, An in vivo model to investigate adipose tissue dysfunction in obesity
Dr Mahetab Amer, University of Leeds, Harnessing Tuneable Biomechanical Cues For The Development of 3D Osteosarcoma Micromodels
Dr Roberto Angelini, Swansea University, The role of the plasmalogen lipid in synaptic function and neurodegeneration
Dr Lindsay Baker, University of Oxford, Understanding death in response to antibiotics in bacterial communities
Dr Roberto Bellelli, Queen Mary University of London, Investigating the roles of DNA Polymerase Epsilon in genome and epigenome stability
Dr Stefan Bidula, University of East Anglia, Targeting G-quadruplexes to modulate secondary metabolite production in Aspergillus spp
Dr Laura Bonnett, University of Liverpool, Predicting risk of next seizure using all seizures along a patient’s journey
Dr Hannah Burgess, University of Surrey, Uncovering the mechanism of coronavirus regulation by m6A RNA modification
Dr Adam Byron, School of Medical Sciences, University of Manchester, Regulation of gene expression by a mechanosensitive nuclear protein network
Dr Yutong Cai, University of Leicester, Interplay between traffic noise and cardiovascular risk factors on the ageing brain
Dr Shin-Yi Chiou, University of Birmingham, RPM: early Rehabilitation with arm-crank exercise training Promoting Motor recovery after spinal cord injury
Dr Mireia Crispin Ortuzar, University of Cambridge, Mapping Metastasis: unravelling treatment response patterns in ovarian cancer
Dr Rebecca Dumbell, Nottingham Trent University, The role of arcuate nucleus ZFHX3 on food intake, growth and metabolism in mice
Dr Daniel Goldhill, Royal Veterinary College, How Did Influenza Virus Evolve To Use A Novel Receptor Protein In Bats?
Dr Ines Hahn, University of York, Understanding the role of local GSK-3β activity for neuronal outgrowth and maintenance
Dr Daniel Hampshire, University of Hull, Understanding the association of von Willebrand factor genetic variation and levels with cardiovascular disease outcomes
Dr Chris Henstridge, University of Dundee, Characterising the synaptic localisation and interactome of TDP-43 in neurodegenerative disease
Dr Gerrit Hilgen, Northumbria University, Channelomics for the aging eye
Dr Marion Hogg, Nottingham Trent University, Investigating the role of tRNA fragments in neurons
Dr Jon Humphries, Manchester Metropolitan University, How does ubiquitin-based protein degradation control adhesion signalling?
Dr Timothy Humpton, Glasgow Caledonian University, Targeting p53 to suppress non-alcoholic steatohepatitis comorbid with type 2 diabetes mellitus
Dr Daniel Johnson, Open University, Risk Factors Influencing Ion Channel Activity and Calcium Handling in Atrial Fibrillation (RisCa-AF)
Dr Ryan Kean, Glasgow Caledonian University, Teaching an old drug new tricks: exploring drug repurposing to combat chronic vaginal infections.
Dr Scott Lovell, University of Bath, A Phage Display Approach to Identify Targeted Covalent Cyclic Peptides for Undruggable Proteins
Dr Maria Maiaru, University of Reading, Investigating the analgesic properties of psilocybin in preclinical models of chronic pain
Dr Yutaka Matsubayashi, Bournemouth University, Investigating the mechanisms that orchestrate basement membrane formation – toward the invention of future therapies
Dr Nazia Mehrban, University of Bath, Novel customisable peptide-based biomaterials for healthcare applications
Dr Nina Milosavljevic, University of Manchester, Biological mechanisms underlying visual influences on mood
Dr Cassandra Modahl, Liverpool School of Tropical Medicine, Identification of endogenous mediators contributing to snake venom-induced cytotoxicity
Dr Peter Nicholls, University of Bradford, Deciphering the rising incidence of germ cell tumours
Dr Nikolas Nikolaou, University of Bath, Determining the cytoplasmic interactome of an RNA splicing regulator during neuronal connectivity
Dr Monica Olcina, University of Oxford, Investigating C5aR1-mediated regulation of tumour cell death
Dr Adjanie Patabendige, Edge Hill University, Blood-brain barrier dysfunction in atrial fibrillation
Dr Binoy Paulose Nadappuram, University of Strathclyde, Development of a single cell biopsy platform to study dynamic transcriptional changes in cancer
Dr Caroline Pellet-Many, Royal Veterinary College, The role of Neuropilins in the modulation of macrophage phenotype during zebrafish heart regeneration
Dr Srikanth Ramaswamy, Newcastle University, Cellular and synaptic effects of histaminergic neuromodulation in the human neocortex
Dr Roseanne Rosario, University of Edinburgh, Defining mechanisms of chemotherapy-induced ovarian damage and the potential for recovery
Dr Alejandra Sel, University of Essex, Measuring the impact of ageing on the physiological mechanisms of action control
Dr Tanya Soliman, Queen Mary University of London, New rules of engagement – Precision mapping of substrates to understand kinase specificity
Dr Joanne Tarver, Aston University, Support in Special Education for Emotions and Resilience in Schools (SUPERSchools)
Dr Lian Tian, University of Strathclyde, Novel therapies targeting the right ventricle in pulmonary arterial hypertension
Dr Anja Winter, Keele University, Combating Chikungunya-induced chronic rheumatoid arthritis
Dr Gareth Wright, University of Essex, BioPROTACs and BioAUTACs for neurodegenerative disease
Springboard round 7 awardees
Dr Erwin Alles, University College London, Non-contact optical ultrasound imaging
Dr Marcelo Andrade de Lima, Keele University, Elucidating the structural requirements for heparin-based inhibitors of SARS-CoV-2 infection
Dr Francesco Baldini, University of Glasgow, A novel approach to assess malaria mosquito biological age to accelerate the implementation of vector control in endemic settings
Dr Jelena Baranovic, University of Edinburgh, Activation of AMPA-type glutamate receptors in health and disease
Dr Adrian Bradu, University of Kent, Next Generation Biopsy
Dr Emma Cheshire, University of Leicester, Increasing the evidence base for the cause of subdural haemorrhage and the source of bleeding in paediatric head injury
Dr Marilena Crescente, Manchester Metropolitan University, Investigating the influence of platelet-derived eicosanoids on NET formation during fungal infection
Dr Chiara Dall'Ora, University of Southampton, Improving patient safety, workforce wellbeing and NHS efficiency through improved shift patterns for nursing staff
Dr Kelly Diederen, King's College London, Predicting psychosis-onset and symptomatic relapse through online assessment of belief-updating and speech organisation
Dr Pei San (Sharel) E, Teesside University, Nanoscale electrochemistry of brain cancer cells
Dr Robert Ferguson, University of Essex, Airborne antimicrobial resistance: identifying the main environmental sources and health impacts
Dr Danna Gifford, University of Manchester, Suppressing mutation-mediated resistance through antibiotic combination treatment
Dr Peter Harvey, University of Nottingham, Expanding the Frontiers of Molecular MRI: Imaging the Inflamed Brain during Neurodegeneration
Dr Sam Hughes, University of Plymouth, Virtually painless? Steps towards mechanism-driven use of immersive virtual reality for chronic pain.
Dr Aravindan Ilangovan, Queen Mary University of London, Understanding the molecular mechanism of antibiotic resistance gene transfer in bacteria
Dr Jun Ishihara, Imperial College London, Next-generation tumour-homing IL-12 expressing CAR-T platform technology to achieve safe and efficacious therapy for solid cancers
Dr Seyed Mehdi Jafarnejad, Queen's University Belfast, Uncovering the mechanism of resistance to RNA-incorporating drugs in cancer
Dr Matt Jones, University of Plymouth, Extracellular matrix-dependent regulation of cell quiescence and proliferation
Dr James Joseph, University of Dundee, Multi-modal Theranostic Endoscope for Intra-operative guidance and Focussed Ultrasound Therapy
Dr JeYoung Jung, University of Nottingham, From neurotransmitters to cognition: The neurochemical mechanism of semantic cognition in frontotemporal dementia
Dr Renata Jurkowska, Cardiff University, Epigenetic editing in human lung cells for discovery of novel drivers and treatments for chronic lung diseases
Dr Eunchai Kang, University of Aberdeen School of Medicine and Dentistry, Investigation of the epitranscriptomic mechanisms of microcephaly using human brain organoids.
Dr Ioanna Keklikoglou, Queen Mary University of London, Exploiting the heterogeneity of circulating extracellular vesicles to predict response to therapy
Dr Jerome Korzelius, University of Kent, Secrets of secretion: the role of Klu-targets in entero-endocrine cell differentiation in flies and humans
Dr Ioannis Kourtzelis, University of York, Myeloid cell phagocytosis mediates innate immune training-dependent tumour suppression
Dr Thomas Lanyon-Hogg, University of Oxford, Defining the chemical space for small molecule accumulation in bacteria
Dr Rachel Lord, Cardiff Metropolitan University, Hypertension in polycystic ovary syndrome: is it my hormones?:The impact of hyperandrogenism on sympathetic vasoconstriction and blood pressure regulation.
Dr Nicola Lynskey, University of Edinburgh, Epigenetic regulation of gene expression in highly virulent group B streptococci
Dr Girish Ram Mali, University of Bristol, Assembly mechanisms of ciliary cytoskeletal motors
Dr Alison McNeilly, University of Dundee School of Medicine, Does Nrf2 provide neuroprotection against diabetes-associated vascular dysfunction?
Dr Paul McVeigh, Queen's University Belfast, Profiling the dynamics of nucleic acid secretion by neglected tropical disease parasites - a route to improved diagnostics?
Dr Fabien Naneix, University of Aberdeen, How does adolescent obesity change the control of dietary decision-making?
Dr Luigi Ombrato, Queen Mary University of London, Characterising neutrophil:macrophage cross-talk in metastatic niches
Dr Bridget Penman, University of Warwick, Predicting infectious disease evolution in light of immune system diversity
Dr Esperanza Perucha, King's College London, Unravelling new immune-regulatory switches by manipulating cellular cholesterol metabolism in humans
Dr David Petrik, Cardiff University, Profiling neurogenic potential of a new anti-obesity compound
Dr Nicole Prior, University of Southampton, Targeting metabolic regulation of hepatocyte differentiation to develop therapeutic strategies for liver disease.
Dr Laura Rivino, University of Bristol, Correlates of Protective Immunity and Immunopathology for Dengue in Obesity and Normal weight
Dr Ediz Sohoglu, University of Sussex, Learning to hear again: Brain mechanisms supporting perceptual learning of degraded speech
Dr Jennifer Southcombe, University of Oxford, Adaptive immune-mediated endometrial tissue dysfunction in recurrent pregnancy loss
Dr Neil Stewart, University of Sheffield, Rapid, Silent Magnetic Resonance Imaging for Infant Lung Disease Assessment
Dr Richard Timms, University of Cambridge, How does specificity within the ubiquitin system regulate the activation and resolution of T cell responses?
Dr Hung-Ji Tsai, University of Birmingham, Investigating the pleiotropic effects of aneuploidy in antifungal resistance.
Dr Ana Viñuela, Newcastle University, Investigating age-related splicing and its links to type 2 diabetes.
Dr Hua Wang, University of Glasgow, Pigments of after-life: a novel innate adaptation and persistence system in Mycobacterium tuberculosis
Dr Mark Williams, Glasgow Caledonian University, Macrophage driven therapy resistance in AML: from macrophage subset characterisation to the potential for therapeutic intervention
Dr Catherine Wilson, University of Cambridge, Developing a cell-free strategy for cardiac regeneration
Dr Adam Wollman, Newcastle University, Dissecting NFkB clusters with single-molecule fluorescence microscopy
Dr Johanna Zumer, Aston University, Utilising advanced neuroimaging methods to assess the reliability of candidate neural biomarkers of attention deficits in children
Springboard round 6 awardees
Dr Ildem Akerman, University of Birmingham, Altering pancreatic beta cell fate through novel regulators
Dr Luke Allsopp, Imperial College London, Bacterial battles in the bid to dominate in chronic respiratory infections - colonisation warfare of Pseudomonas aeruginosa respiratory strains
Dr Paul Anastasiades, University of Bristol, The role of the cerebellum in thalamic development
Dr Hrvoje Augustin, Royal Holloway, University of London, Identification of novel modifiers of synaptic function, neurodegeneration and longevity in a Drosophila FTD/ALS model
Dr Andrew Beekman, University of East Anglia, Controlling the protein-protein interactions of telomerase
Dr Daniel Booth, University of Nottingham, Characterising Novel Regulators of Myelination
Dr Dave Boucher, University of York, Unravelling Inflammatory Caspases Co-regulation
Dr Melissa Bowerman, Keele University School of Medicine, Combining bioinformatic and drug repurposing approaches to develop second-generation therapies for spinal muscular atrophy
Dr Han-Jou Chen, University of York, Road to neurodegeneration: characterisation of a novel TDP-43 mutation in motor neurone disease pathogenesis
Dr Anissa Chikh, St George's, University of London, Unraveling the novel role of iRHOM2 in the nucleus
Dr Delma Childers, University of Aberdeen, The unexpected consequences of antifungals on innate immune interactions
Dr Carolina Coelho, University of Exeter, Dynamics of brain invasion by the pathogenic fungus Cryptococcus neoformans
Dr Lucy Crouch, University of Birmingham, Mucin degradation by prevalent gastrointestinal human pathogens
Dr Ravi Das, University College London, A Neurosignature of Memory Destabilisation: Developing Tools to Rewrite Food Reward Memories and Treat Overeating Disorders
Dr Tim Davies, University of Durham, Cell identity: an essential aspect of animal cell division
Dr Suman De, University of Sheffield, Defining nanoscopic structure-function relationship of α-Synuclein aggregates in neurodegenerative disorders
Dr Samuel Dean, Warwick Medical School, Investigating flagellum central pair nucleators in the protozoan pathogen Trypanosoma brucei
Dr Edward Emmott, University of Liverpool, Exploiting and advancing single-cell proteomics to identify novel pathways to disrupt RNA virus infection
Dr Andrew Greenhalgh, University of Manchester, Defining brain region-specific immune responses driving concussion-related injury
Dr Timothy Grocott, University of East Anglia, Harnessing self-organisation in human retinal organoids
Dr Ruth Hackett, King's College London, The cross-national impact of discrimination on health: considering social and genetic vulnerabilities
Dr Sarah Hill, Royal Veterinary College, Viruses at the human-livestock interface: improved genomic detection and prediction of zoonotic viruses that harm Kenyan pastoralists
Dr Maria Angeles Juanes Ortiz, Teesside University, Molecular coordination between cytoskeletal networks in collective cell migration and its impact on development and disease
Dr Robert Koechl, King's College London, Investigating the role of WNK1 in T cell killing
Dr Katja Kornysheva, University of Birmingham, Neural basis of sequence planning in motor coordination disorders
Dr Saloni Krishnan, Royal Holloway, University of London, The neural and cognitive basis of motivation in adolescents with reading disorder
Dr Maisem Laabei, University of Bath, Dissecting complement resistance in Staphylococcus aureus
Dr Alvina Lai, University College London, Harnessing large scale clinical-genomic resources for cancer care: Validity, multimorbidity and clinical decision making
Dr Bernard Liew, University of Essex, Computational methods towards monitoring in-vivo hip joint loads during physical exercises (CHOOSE)
Dr Elisabeth Lowe, Newcastle University, Characterising a new family of glycoside hydrolases that target mycobacterial cell wall glycans
Dr Elena Mancuso, University of Ulster, Custom 3D printed implantable biomedical devices for guided mandible bone regeneration
Dr Ronan McCarthy, Brunel University London, Antibiofilm Wound Dressings Designed to Prevent Infection and Minimize the Risk of Bacteraemia and Sepsis
Dr Conor Meehan, University of Bradford, Incorporating whole genome diversity into the clinical epidemiology of Mycobacterium tuberculosis
Dr Madhvi Menon, University of Manchester, Investigating aberrant B cell responses in a clinically diverse cohort of COVID-19 patients
Dr Josie Millar, University of Bath, Improving and maintaining mental health: Development of a blended intervention for relapse prevention in Obsessive Compulsive Disorder (OCD)
Dr Joanna Moss, University of Surrey, Autistic Traits and Mental Health in Females with the Fragile X Premutation: A Multi-Level Study of Behavioural, Cognitive and Genetic Profiles
Dr Liliane Mukaremera, University of Exeter, Roles of Cryptococcus cell wall dynamics during infection and antifungal drug resistance
Dr Ben Newland, Cardiff University, Creating the first glucose releasing biomaterials for improving cell therapies
Dr Tony Nolan, Liverpool School of Tropical Medicine, Synergizing Two Forms of Vector Control: Insecticides and Gene Drive
Dr Rhiannon Owen, Swansea University, Developing statistical methods to improve the diagnosis and care of hospitalised patients with COVID-19
Dr Nicola Paine, Loughborough University, Interactions between physical activity, sedentary behaviour and immune reactivity to acute psychological stress - implications for Cardiovascular Disease (CVD)
Dr Aleks Ponjavic, University of Leeds, Zooming in on adaptive immunity with high-speed super-resolution microscopy
Dr Linus Schumacher, University of Edinburgh, Computational framework for modelling immune cell migration in tissue repair and the origins of cancer
Dr Gabriel Sollberger, University of Dundee, Establish new model systems to understand human neutrophil biology
Dr Athina Spiliopoulou, University of Edinburgh, Identifying genetic factors of progression and treatment response in autoimmune diseases using genetics of biomarkers and Bayesian shrinkage prediction
Dr Lovorka Stojic, Queen Mary University of London, Understanding the mechanisms how long noncoding RNAs control genome stability in cancer
Dr Sana Suri, University of Oxford, Multimorbidity in Brain and Cognitive Ageing
Dr Kerstin Timm, University of Oxford, Mitochondrial function in doxorubicin-induced cardiotoxicity
Dr Julien Vaubourgeix, Imperial College London, Phenotypic resistance induced by sequential antibiotic exposure in Mycobacterium tuberculosis
Dr Mark Wade, University of Hull, Investigation of chromatin-bound CBX2-associated protein complexes in advanced cancer
Dr Andrew Wood, University of Exeter, Using genetics to understand changes in body weight over time and links to disease
Dr Wenfeng Xia, King's College London, All-optical Photoacoustic and Fluorescence Endomicroscopy Probe for Guiding Minimally Invasive Surgery
Dr Briony Yorke, University of Bradford, Research Investigating the molecular basis of cataract formation using time-resolved crystallography
Dr Jie Zheng, University of Bristol, Identification of drug targets for cardio-metabolic diseases through integration of proteome and trajectories of intermediates
Springboard round 1 awardees
Dr Anna Barnard, Imperial College London, Selective Helix-Mimetics as Tools in Malaria Research.
Dr Christos Bergeles, University College London, 3D In-Focus Endoscopic Imaging with Light-Field Cameras: Optomechatronics and Algorithms.
Dr Maike Bublitz, University of Oxford, Proton Transporting ATPases: Structural and Functional Studies of Fungal Proton Pumps.
Dr Angus Cameron, Queen Mary University of London, Defining the role of PKN2 in cancer-associated fibroblasts.
Dr Richard Chahwan, University of Exeter, Chromatin modifications in genomic stability, immune diversity, and tumorigenesis.
Dr Edwin Chen, University of Leeds, Role of CHD4 Helicase in Malignant Megakaryopoiesis.
Dr Mihaela Crisan, University of Edinburgh, Investigate the link between the two hematopoietic stem cell types: different origins, different niches or both?
Dr Molly Crockett, University of Oxford, Identifying risk factors for personality disorder using computational neuroimaging and ecological momentary assessment.
Dr Margaret Cunningham, University of Strathclyde, A multi-disciplinary approach to thrombin receptor research – A focus on the interrogation of the Proteinase-activated Receptor 4 (PAR4) interactome.
Dr Alice Davidson, University College London, Investigating TCF4 triplet-repeat-mediated pathogenic mechanisms associated with Fuchs endothelial corneal dystrophy (FECD), a visually devastating and common age-related disease.
Dr Emma Dempster, University of Exeter, Using functional epigenomics to dissect the molecular architecture of schizophrenia.
Dr Catherine Hall, University of Sussex, How does Apolipoprotein E4 affect brain oxygenation and blood flow?
Dr Sian Henson, Queen Mary University of London, Investigating the dynamics of senescent human T-cell trafficking.
Dr Daniel Horton, University of Surrey, Understanding constraints and drivers acting on viruses that cross species barriers, using rabies virus as a model.
Dr Benjamin Lehne, Imperial College London, A trans-ethnic gut microbiome study of insulin resistance.
Dr Florian Merkle, University of Cambridge, Regulation of human neurones that promote feeding
Dr Emily Noël, University of Sheffield, The second heart field and cardiac morphogenesis – using transcriptomics to unravel heart development.
Dr Paulo Ribeiro, Queen Mary University of London, The Interplay Between Polarity and Hippo Signalling in the Regulation of Tissue Growth.
Dr Samantha Terry, King's College London, Radiobiological assessment of radionuclides used for therapy; how can they be used effectively?
Springboard round 2 awardees
Dr Kate Baker, University of Liverpool, Multi-species models of antimicrobial resistance emergence and persistence, developed from real world epidemics.
Dr Marcella Bassetto, Cardiff University, Novel therapeutic strategies to overcome opsin misfolding and aggregation in retinal blinding diseases.
Dr Tim Blower, Durham University, Regulating bacterial growth through toxin-antitoxin systems.
Dr Peter Cook, University of Manchester, Defining the key human innate immune cells that control anti-fungal immunity and inflammation.
Dr Laura Ferraiuolo, University of Sheffield, The involvement of exosomal RNA in astrocyte-mediated toxicity in motor neurone disease.
Dr Juan Fontana, University of Leeds, Elucidating the structure of previously inaccessible fusion intermediates of Influenza A Virus by cryo-electron microscopy.
Dr James Garnett, Queen Mary, University of London, A multidisciplinary approach to identify new antibacterial targets within biofilms.
Dr Katie Gillies, University of Aberdeen, Feedback matters: How should trial results be reported back to participants?
Dr Jamie Johnston, University of Leeds, Optical mapping of olfactory circuitry.
Dr Antreas Kalli, University of Leeds, Membrane transport proteins: Understanding the red cell Band 3 anion exchanger function.
Dr Peter Keating, University College London, Developmental impact of intermittent hearing loss on spatial hearing in noisy environments
Dr Tiziana Lembo, University of Glasgow, Understanding cultural, social and epidemiological drivers of human anthrax infection in rural African communities.
Dr David Llobet-Navas, Newcastle University, Control of somatic reprogramming by the microRNA cluster-424/503 during breast tumorigenesis and its relation with pregnancy.
Dr Christian Nielsen, Queen Mary University of London, Organic Bioelectronic Sensors for Epilepsy Diagnosis.
Dr Michael Okun, University of Leicester, How do individual neurons engage in resting-state infraslow dynamics of the cortex?
Dr Alice Pollitt, University of Reading, Impact of Podoplanin signalling complexes on the separation of the lymphatic and blood vasculatures in vivo.
Dr Andela Saric, University College London, Amyloid aggregation: Inhibition of self-replication and membrane-mediated control.
Dr Inez Schoenmakers, University of East Anglia, Does vitamin D supplementation have anabolic effects on the osteocyte and does it benefit the renal-bone axis?
Dr Amanda Sferruzzi-Perri, University of Cambridge, Materno-fetal resource allocation; altering placental endocrine function by IGF2.
Dr Yihua Wang, University of Southampton, The role of Factor inhibiting HIF (FIH) in the development of idiopathic pulmonary fibrosis (IPF)
Springboard round 3 awardees
Dr Shoba Amarnath, Newcastle University, The role of PD-1 in modulating ILC-2s in the tumour microenvironment
Dr Andrew Atkin, University of East Anglia, Age-related changes and determinants of physical activity, sedentary behaviour and sleep in young people
Dr Nicolas Barry, University of Bradford, Understanding the anticancer properties of metal-based drug candidates
Dr Akshay Bhinge, University of Exeter, Investigating the interactions of noncoding RNAs and aging pathways in driving motor neuron degeneration in ALS
Dr Lucy Bowes, University of Oxford, Adolescents at-risk of depression: examining the role of bullying as a causal risk factor using polygenic risk scores and virtual reality
Dr Ruth Bowness, University of St Andrews, Using individual-based mathematical models to study antibiotic resistance. (GCRF)
Dr Jonathan Cox, Aston University, Investigating the physiology of non-replicating persistent mycobacteria for latent tuberculosis drug discovery. (GCRF)
Dr Frank Dondelinger , University of Lancaster, Predicting clinical progression in biologically heterogeneous neurodegenerative diseases
Dr Maria Fragiadaki, University of Sheffield, Growth-hormone/STAT5 signalling in the polycystic kidney – using transcriptomics to unravel pathogenesis.
Dr Catherine Grainger, University of Stirling, Remembering to remember: What techniques can be used to improve prospective memory in individuals with autism spectrum disorder (ASD)?
Dr James Hewitson, University of York, Do helminth-induced antibodies restrain macrophages in type-2 immunity? (GCRF)
Dr Michelle Holland, King's College London, Developmental programming of ribosomal DNA epigenetics: what is the functional link to metabolic disease risk?
Dr David Hughes, University of St Andrews, Posttranslational control of our innate immune response: exploring a novel role for ISGylation.
Dr Asif Iqbal, University of Birmingham, Investigating the role of galectins in chronic inflammation associated with atherosclerosis
Dr Yi Jin, Cardiff University, A chemical biology approach to control sepsis. (GCRF)
Dr Diana Jurk, Newcastle University, How does cell senescence impact on the ageing brain?
Dr Paul Kasher, University of Manchester, Identifying novel molecular regulators of brain injury following intracerebral haemorrhage
Dr Jemma Kerns, University of Lancaster, How does gene and protein expression, of collagen, affect the chemical and material properties of osteoarthritic bone?
Dr Matthew Loxham, University of Southampton, Redox Balance and Ferroptosis – A New Mechanism Behind the Health Effects of Air Pollution?
Dr MaryAnn Noonan, University of Oxford, The development of goal-directed behaviour and the underlying neural architecture across adolescence
Dr Linda Oude Griep , Imperial College London, A systems approach to reveal complex metabolic relations of fruit and vegetable consumption on cardiovascular health
Dr Catherine Pashley, University of Leicester, When biomes meet: Characterisation of bacterial and fungal microbiota in the airways of people with asthma and the impact of antimicrobial agents.
Dr Lavinia Paternoster, University of Bristol, Identification of drug targets for atopic dermatitis through multi-omic data integration
Dr Danielle Paul, University of Bristol, Cryo-Electron microscopy of cardiac thin filaments: Heart disease on a molecular level
Dr Elena Rainero, University of Sheffield, Unravelling extracellular matrix endocytosis in breast cancer
Dr Emma Robinson, King's College London, What makes your mind unique? Tailoring brain network models to individuals to enhance predictions of neurological development and disease
Dr Sebastian van de Linde, University of Strathclyde, Tuneable photoswitches for chromatic aberration-free multicolour super-resolution imaging
Dr Kirsty Wan, University of Exeter, Genesis and control of ciliary beating: a new look at an ancient structure. (GCRF)
Dr Jun Wang, Queen Mary University of London, Characterisation of functional non-coding mutations in follicular lymphoma
Dr Sarah White, University College London, Strengths and weaknesses in non-verbal communication in autism
Dr Helge Wurdemann, University College London, Stiffness and position control for soft robotic devices suitable for colo-rectal surgery
Dr Giulia Zanetti, University College London , Visualising the role of TANGO1 in COPII-mediated procollagen transport by cryo-EM
Springboard round 4 awardees
Dr Louise Atkinson, Queen's University Belfast, Exploiting CRISPR/Cas9 for the Control of Parasitic Nematode NTDs. (GCRF)
Dr Kirsty Bannister, King's College London, Defining descending modulatory pathways that regulate spinal nociceptive processing
Dr Samir Bhatt, Imperial College London, Unravelling and predicting the spatiotemporal structure of infectious disease outbreaks. (GCRF)
Dr Catalin Chimerel, University of Exeter, Measuring antibiotic permeation in single bacteria with absorption spectroscopy
Dr Owen Davies, Loughborough University, Deciphering molecular crosstalk in the musculoskeletal system: vesicle-mediated communication and its impact on bone health
Dr Maria Deprez, King's College London, Artificial intelligence to characterise abnormal brain development and neurocognitive disorders
Dr Athanasios Didangelos, University of Leicester, New proteomics and molecular approaches to study IgA Nephropathy
Dr Rebecca Drummond, University of Birmingham, Role and Control of the Functional Specialisation of Microglia during Fungal Meningitis
Dr Emanuele Giorgi, Lancaster Medical School, Spatio-temporal variation of malaria transmission in Africa: modelling, capacity-building and translating research into practice. (GCRF)
Dr Alice Giustacchini, University College London, Investigating the Implications of Stem Cell Metabolic Heterogeneity in Normal and Malignant Hematopoiesis
Dr Caroline Gorvin, University of Birmingham, Manipulating GPCR heterodimerisation for novel obesity and tumour therapies
Dr Stuart Greenhill, Aston University, Network Dynamics of Focal Cortical Dysplasia
Dr Gisela Helfer, University of Bradford, The role of hypothalamic tanycytes in the circadian control of energy metabolism
Dr Brian Hudson, University of Glasgow, Long Chain Fatty Acid Mediated Communication Between Metabolism and Inflammation as a Potential Therapeutic Target for Type 2 Diabetes
Dr Nicola Irwin, Queen's University Belfast, Responsive hydrogel platforms towards the prevention of urinary catheter infections and blockages
Dr Katherine Keenan, University of St Andrews, Social inequalities in chronic disease trajectories in mid and later life: taking account of multimorbidities. (GCRF)
Dr Johnathan Labbadia, University College London, Investigating the interplay between mitochondrial signalling and cytosolic protein homeostasis
Dr Jorn Lakowski, University of Southampton, Modelling retinitis pigmentosa associated cone photoreceptor death using stem cell derived organoids
Dr Paul Miller, University of Cambridge, Developing novel modulators of GABA-A receptors
Dr Luca Modenese, Imperial College London, Computational framework for patient-specific surgical planning of knee osteotomies
Dr Giovanna Nalesso, University of Surrey, Role of Calcium Calmodulin Kinase II in the modulation of lipid metabolism in the articular chondrocytes
Dr Dimitrios Papadopoulos, University of Edinburgh, Cell-to-cell variability in the concentration and chromatin-binding kinetics of pioneer transcription factors coordinate vertebrate development
Dr Christopher Rhodes, Imperial College London, Functional and epigenomic characterisation of genetic associations in pulmonary arterial hypertension
Dr James Robinson, University of Leeds, Defining the spatial requirements for therapeutic modulation of signaling through FcγRIIa
Dr Kevin Rouault-Pierre, Queen Mary University of London, Stress integration in normal and malignant haematopoietic stem cells
Dr Gabriele Schweikert, University of Dundee, Novel Machine Learning Techniques to Elucidate Function and Dynamics of Epigenomic Mechanisms
Dr Maria Secrier, University College London, Quantitative evaluation of gene dosage and genomic instability effects on metastatic transformation of solid cancers
Dr Tatyana Shelkovnikova, Cardiff University, Developing tools to monitor expression of lncRNA NEAT1 isoforms for basic research and drug discovery
Dr Mirre Simons, University of Sheffield, Mechanisms of age-dependent effects of reduced mTor signalling on life expectancy: towards short-term treatments for ageing-related disease
Dr Ana Tiganescu, University of Leeds, Regulation of skin function and wound healing by pre-receptor glucocorticoid metabolism in diabetes
Dr Jessica Tyrrell, University of Exeter, Using genetics to understand the complex relationships between obesity and depression in diverse global settings. (GCRF)
Dr Alessio Vagnoni, King's College London, Linking mitochondrial transport and function in ageing Drosophila neurons.
Dr Maarten Zwart, University of St Andrews, The circuit basis of descending motor control: fast whole-brain activity imaging at cellular resolution
Dr Dennis Wang, University of Sheffield, Evidencing subtypes of disorders with comorbidities through a consensus of clinical and multi-omic traits
Springboard round 5 awardees
Dr Scott Allen, University of Sheffield, Investigating how the MGO-NRF2 cellular protection pathway is affected in amyotrophic lateral sclerosis (ALS).
Dr Heather Bailey, University College London, Understanding the consequences of congenital cytomegalovirus infection: a feasibility study.
Dr Manuel Banzhaf, University of Birmingham, Creating a genome-wide mycobacterial stress-response map. (GCRF)
Dr Sarah Bath, University of Surrey, Is mild-to-moderate iodine deficiency in pregnancy a risk factor for hearing impairment in children?
Dr Megan Bergkessel, University of Dundee, Measuring activity dynamics in non-growing populations of bacteria.
Dr Valerie Brandt, University of Southampton, Investigating mechanisms of change and their neural underpinnings in patients with tic disorders receiving habit reversal training.
Dr Rochelle Burgess, University College London, Mapping patterns of risk and resilience to mental health consequences of child marriage in Zimbabwe (MARCH). (GCRF)
Dr Bernadette Carroll, University of Bristol, Spatial regulation of mTORC1 in Tuberous Sclerosis.
Dr Alan Cartmell, University of Liverpool, What features of bacterial carbohydrate sulfatases can be exploited for human health?
Dr Ines Cebola, Imperial College London, Investigation of NAFLD-associated epigenetic dysregulation.
Dr Liye Chen, University of Oxford, Investigating the functional basis of shared genetic risks across immune-mediated inflammatory diseases.
Dr Gemma Clarke, University of Leeds, Understanding access to palliative care by ethnic minority groups in the UK: with a focus on South Asians and those with refugee or asylum seeker status.
Dr Rebecca Coll, Queen's University Belfast, Investigating the regulation of the human NLRP3 inflammasome.
Dr James Connolly, Newcastle University, Deciphering the regulatory mechanisms underpinning niche-adaptation of pathogenic Escherichia coli during systemic infection.
Dr Anne Cori, Imperial College London, Developing reliable epidemic forecasting using branching processes: Ebola as a case study.
Dr Lauren Cowley, University of Bath, Novel machine learning models for real time pathogen management.
Dr David Doupe, Durham University, Stem Cell Derived Signals in Intestinal Stem Cell Homeostasis.
Dr Niharika A Duggal, University of Birmingham, Gut microbiome dysbiosis and immune ageing: investigating associations and potential for novel therapies.
Dr Antonio Fernández Pardiñas, Cardiff University, PATRON - Pharmacogenomics of Antipsychotic Treatment and Response.
Dr Maria Filippetti, University of Essex, Understanding the developmental mechanisms underlying emotional eating.
Dr Taya Forde, University of Glasgow, A novel targeted sequencing approach for untangling the epidemiology of endemic anthrax, a neglected zoonosis. (GCRF)
Dr Rene Frank, University of Leeds, The in situ molecular architecture of Alzheimer’s disease pathology.
Dr Jennifer Greaves, Coventry University, Investigating the function and substrate interaction network of ABHD16A, a novel regulator of protein S-acylation.
Dr James Hall, University of Liverpool, Understanding the spread of multi-resistance megaplasmids in Pseudomonas.
Dr Sally Hargreaves, St George's University of London, Developing and testing an innovative multi-disease screening and catch-up vaccination tool to strengthen delivery systems to migrants in UK primary care.
Dr Musa Hassan, University of Edinburgh, Using single-cell dual RNA sequencing to interrogate host immunity to pathogens.
Dr Kristina Kirschner, University of Glasgow, What is the role of secondary senescence in disease? Elucidating the role of Notch signalling in secondary senescence.
Dr Efterpi Kostareli, Queen's University Belfast, Epigenetic effects of BTK inhibition in chronic lymphocytic leukaemia.
Dr Eneko Larrañeta, Queen's University Belfast, Intranasal implantable devices for prolonged drug delivery in schizophrenic patients.
Dr Bethan Lloyd-Lewis, University of Bristol, Deciphering the contribution of development and age to breast cancer aetiology
Dr Leeanne McGurk, University of Dundee, Defining novel therapeutic targets for TDP-43-associated neurodegenerative disease.
Dr Erik Mire, Cardiff University, Deciphering the interplay between maternal obesity and neuroimmune interactions during brain development.
Dr Síle Molloy, St George's University of London, Impact of combined oral therapy of fluconazole plus flucytosine for treatment of asymptomatic cryptococcal antigen positive patients in advanced HIV patients in Tanzania: A single arm intervention trial. (GCRF)
Dr Valentina Mosienko, University of Exeter, Novel mechanisms in depression: investigating the effects of astrocytic lactate on emotional behaviour.
Dr Ana Namburete, University of Oxford, Ultrasound-Based Assessment of Brain Folding Patterns in Early Pregnancy.
Dr Laura Nellums, University of Nottingham, EMERGE: Examining Migration and the Epidemiology of Resistance in Groups in Europe.
Dr Graham Norquay, University of Sheffield, Using hyperpolarised 129Xe MRI to evaluate tumour hypoxia in patients with lung cancer.
Dr Patricia P. Esteban, Aston University, A novel microfluidic co-culture platform to study functional responses of neuronal and glial cells ex vivo.
Dr Sebastian Pattinson, University of Cambridge, 3D Printing Imperceptible Orthoses with Biomimetic Geometry and Molecular Structure to Enable Healthy Gait.
Dr William Peveler, University of Glasgow, Fluorescent Sensor Arrays for Serum-Based Liver Fibrosis Detection.
Dr James Smith, University of East Anglia, Investigating cardiomyocyte communication in hypertrophic cardiomyopathy.
Dr Laura Southgate, St George's University of London, Characterisation of the cellular role of ATP13A3 and functional impact of variation underlying pulmonary arterial hypertension.
Dr Rachel Sparks, King's College London, Learning Movement Signatures from Video-Telemetry to Localize Epileptic Seizures.
Dr George Stothart, University of Bath, Developing functional biomarkers of early Alzheimer's disease.
Dr Clare-Louise Towse, University of Bradford, Role of isomerisation in cardiac amyloidosis.
Dr Patrick Walker, Imperial College London, Evaluation of the potential for rapid diagnostic testing for malaria within antenatal care to provide sustainable, dynamic and scalable malaria surveillance. (GCRF)
Dr Gernot Walko, University of Bath, Targeting YAP/TAZ as a novel therapeutic strategy in cutaneous squamous cell carcinoma.
Dr Helen Waller-Evans, Cardiff University, Developing an NPC1 activity assay using the novel fluorescent substrate AQ2 for use in basic research and drug discovery.
Dr Qian Wu, University of Leeds, Defining the structural mechanism of the cellular response to DNA interstrand crosslink lesions.
