Starter Grants for Clinical Lecturers

Hussein Al-Mossawi, University of Oxford, Single cell transcriptomic analysis of the T cell compartment in psoriatic arthritis

Nishkantha Arulkumaran, University College London, A New Antibacterial Route to Selectively Rupture Bacterial Membranes

Vian Azzu, University of Cambridge, The role of monocyte metabolism and signalling in non-alcoholic fatty liver disease

Mohammed Zaeem Cader, University of Cambridge, The role of FAMIN in controlling macrophage lipid biology and restricting inflammation

Johnathan Cooper-Knock, University of Sheffield, Characterisation of a novel genetic variant discovered by exome sequencing in familial amyotrophic lateral sclerosis

Felicity Fitzgerald, University College London, Carriage of antimicrobial resistant bacteria in children in Zimbabwe

Pankaj Garg, University of Sheffield, Whole heart, four-dimensional flow magnetic resonance imaging for accurate assessment of right and left heart flow haemodynamics

Alexandra Gilbert, University of Leeds, Developing predictive models of pelvic radiotherapy-related toxicity using patient reported outcomes

Rachel Guest, University of Edinburgh, Identifying novel genetic drivers of cholangiocarcinoma in primary sclerosing cholangitis

Melanie Hezzell, University of Bristol, Does surgical implantation of a novel bioprosthetic valved conduit in the right ventricular outflow tract affect right ventricular structure and function in healthy pigs?

Laura Jardine, Newcastle University, The evolution of clonal haematopoiesis in individuals with heterozygous GATA2 mutation

Simon Johnston, University of Nottingham, Effect of FoxA1 mutations on the transcriptional response to tamoxifen in lobular breast cancer

Paul Maciocia, University College London, A simple and non-genotoxic method to produce 'off the shelf' allogeneic chimeric antigen receptor T-cells

Barry Main, University of Bristol, Exploring strategies for implementing core information sets for informed consent to surgery for head and neck cancer: operationalising Montgomery

Thomas McKerrell, University of Cambridge, Single cell transcriptome profiling of mutant haematopoietic stem and progenitor cells (HSPCs) in patients with myeloproliferative neoplasms (MPN) enrolled in the TAMARIN clinical trial

Charlotte Pawlyn, Institute of Cancer Research, Developing 3D ex vivo models to study novel therapies targeting high-risk myeloma.

Michele Petruzzelli, University of Cambridge, Implicating the metabolic burden of anti-cancer immunity in cancer cachexia

Anvesha Singh, University of Leicester, Role of elastin in aortic remodelling in bicuspid and tricuspid aortic stenosis- a pilot metabolomics and MRI study

Carol Sinnott, University of Cambridge, Operational failures in general practice: An observational study of what general practitioners do and what gets in the way of doing it

Colin Steele, University of Glasgow, Characterising CXCR2 expressing neutrophils in colorectal liver metastases

Lisa Story, King's College London, MRI assessment of the cervix in non-pregnant women at risk of premature birth; a useful tool for assessment of cervical incompetence?  A pilot study

Mark Thomas, University of Birmingham, Impact of GPVI inhibition on fibrin-mediated platelet responses

Thomas Treibel, University College London, Comprehensive Myocardial Phenotyping in Aortic Stenosis

Timothy Walker, University of Oxford, Whole-genome sequencing M. tuberculosis in a remote, high burden setting

Yin Wu, University College London, Investigating the immune regulation of non-small cell lung cancer by gamma-delta T-cells

Kenny Yu, University of Manchester, Dissecting the heterogeneity of neuroinflammation in low grade and transforming astrocytomas using single cell RNAseq

Sarah Alderson, University of Leeds, An interrupted time series analysis of the Campaign to Reduce Opioid Prescribing

Marc Bailey, University of Leeds, Imaging pathological vascular remodelling in abdominal aortic aneurysm using [18F]Fluorothymidine

Harry Bulstrode, University of Cambridge, Studying gliomagenesis using defined mutations in primary human brain cells

Faye Cooles, Newcastle University, Early RA patient stratification by interferon gene signature – towards optimising clinical outcomes

Rebecca Hill, Newcastle University, Characterising and understanding the mutational landscape of relapsed medulloblastoma

Sarah Howles, University of Oxford, The role of High Mobility Group Nucleosomal Binding Protein 1 in the regulation of urinary calcium excretion.

Aadil Khan, Institute of Cancer Research, Elucidating the drivers of radiation fibrosis in normal tissues: a translational study of neoadjuvant breast radiotherapy and free flap reconstruction

Simon Lambden, University of Cambridge, The role of the pulmonary endothelial HIF isoforms in regulating systemic vascular function

Eileen Parkes, Queen’s University of Belfast, Investigating the immune response to neoadjuvant chemotherapy in breast cancer

Lucia Possamai, Imperial College London, Interactions between Kupffer cells and monocytes in sterile liver inflammation

Paul Ryan, Queen Mary University of London, Investigating phenotypic and functional heterogeneity in γδ T cells

Marietta Stadler, King’s College London, Exploring the barriers to a safe diabetes control in people with type 1 diabetes and eating disorders through better understanding of the psychological and physiological triggers leading to insulin omission

Victoria Stoll, University of Birmingham, Advanced Cardiovascular Magnetic Resonance Techniques to Identify Novel Imaging Biomarkers of Disease Progression and Therapeutic Response in Congenital Heart Disease

Kate Tatham, Imperial College London, The Role of the Lungs in Monocyte Dysfunction in Sepsis

Sofia Theodoropoulou, University of Bristol, The role of mast cells in the pathophysiology of age-related macular degeneration

Kate Walker, University of Nottingham, Childbirth experience questionnaire 2: validating its use in the United Kingdom

Steven Williams, King’s College London, A combined optical and electrogram mapping system to determine the impact of atrial remodelling on electrogram morphology

Tom Wingfield, University of Liverpool, END-TB: enhancing TB control by mitigating catastrophic costs of TB-affected households

Paolo Biancheri, University of East Anglia, Proteolytic degradation of anti-tumour necrosis factor (TNF)-alpha and anti-integrin agents: correlation with response to treatment in inflammatory bowel disease (IBD)

Delanjathan Devakumar, University College London, Long-term effects of the Indian Ocean tsunami in Sri Lankan adolescents

Jessica  Eccles, University of Sussex, Applying leading-edge multimodal neuroimaging and neural connectivity tools to characterise brain mechanisms that link joint hypermobility to anxiety

Amy Foulkes, University of Manchester, STRATOSPHERE: STRATification Of Systemic Psoriasis THERapiEs

Alex Gordon-Weeks, University of Oxford, Fibroblast Growth Factor Receptor Inhibition for Vascular Normalisation and Chemosensitisation

Adam Handel, University of Oxford, Identifying pathogenic T-cell clones in autoimmune demyelinating disease using single cell sequencing

George Harston, University of Oxford, 3D pH-weighted Imaging in Acute Ischaemic Stroke

Jennifer Haworth, University of Bristol, Mechanisms of oral Streptococcus-induced platelet activation

James Hunter, University of Oxford, The effect of Normothermic machine perfusion of kidneys on mitochondrial function

Ivan Koychev, University of Oxford, Indoor and outdoor spatial navigation as a potential biomarker of preclinical Alzheimer's Disease

Oliver Lyons, King's College London, Endothelial patterning in venous valve development

Angus Macleod, University of Aberdeen, Individual-patient-data meta-analysis of prognostic studies in Parkinson's disease

Filipe Martins, University of Cambridge, PTEN expression as a biomarker for targeted therapies in high-grade serous ovarian cancer (HGSOC)

Georgios Oikonomou, University of Liverpool, Using genomics to prevent lameness-causing foot lesions in dairy cattle

Meghan Perry, University of Edinburgh, The use of metagenomics of hospital sewage as an AMR surveillance tool

Ricardo Petraco, Imperial College London, Real-time derivation of coronary pressure-flow slopes and development of novel, stenosis-specific and flow-independent parameters of stenosis severity: towards the application of invasive physiology in unstable haemodynamic conditions

Owen Pickrell, Swansea University, Using natural language processing software to enrich routinely collected electronic data for epilepsy research.

Lynne Sykes, Imperial College London, The interaction between gut microbiota, the systemic immune response and the risk of preterm labour

Karin Tuschl, University College London, Dissecting the mechanisms of manganese dyshomeostasis in disorders of manganese transport

Emma Wall, University College London, Identifying determinants of poor outcome in adult Streptococcus pneumoniae meningitis by transcriptional profiling

Michelle Williams, University of Edinburgh, Combined magnetic resonance coronary angiography and positron emission tomography in patients with coronary artery disease

Tim Williams, University of Cambridge, The role and utility of urinary exosomes in individuals with renal and urinary tract disorders

Kanmin Xue, University of Oxford, Enhancement of dual vector gene therapy for Stargardt disease through

James Alix, University of Sheffield, Developing in vivo Raman Spectroscopy for neuromuscular disease.

Rahul Bhatnagar, University of Bristol, The Semi-rigid Pleuroscopy In Routine Pleural Infection (SPIRIT) Trial

Adam Brown, University of Cambridge, Integration of anatomical imaging and biomechanics for the prediction of coronary plaque growth and rupture

Manil Chouhan, University College London (UCL), Hameodynamic Assessment of Beta-Blocker Therapy for Portal Hypertension using MRI

Thomas Darton, University of Sheffield, Investigating the effects of environmental exposure to fluoroquinolone-resistant Enterobacteriaceae on the gastrointestinal microbiota of children in Nepal

Antonio de Marvao, Imperial College London, Left ventricular hypertrophy in West Africans: discovery of genetic and environmental determinants using 3D imaging-genetics

Charlotte Elder, University of Sheffield, The pharmacokinetic evaluation of a novel non-invasive Short Synacthen Test in Children

David Eyre, University of Oxford, Complete bacterial genome sequencing and mathematical modelling to control healthcare-associated infection

Montserrat Fuste, King's College London, Identifying gene expression and neuroimaging markers for postpartum psychosis

Sherif Gonem, University of Leicester, Effect of environmental exposures on asthma symptoms, lung function and airway inflammation

Sara Hillman, University College London (UCL), An integrated multi-omic analysis of human T-regulatory cells and their role in pregnancies affected by pre-eclampsia

Rachel Jennings, University of Manchester, Molecular dissection of the transcriptome regulating differentiation from the early human embryonic pancreas.

Dan Jones, Queen Mary, University of London, The investigation of the effect of inorganic nitrite/nitrate on contrast induced nephropathy (CIN) after percutaneous coronary intervention (PCI).

Alasdair Jubb, University of Cambridge, Quantifying glucocorticoid induced chromatin reorganisation and genomic responses in human monocytes

Yee-Haur Mah, St George's, University of London, Unified high-dimensional modelling of chronic and acute injury in stroke

Benedict Michael, University of Liverpool, Identifying adjunctive therapy targets to mitigate leucocyte infiltration in herpes simplex encephalitis

Samiul Mostafa, University of Oxford, Determining optimal cardiovascular risk factor levels for individuals with type 2 diabetes mellitus (T2DM)

Amara Nwosu, University of Liverpool, The study of hydration status and complex symptoms in advanced cancer using bioelectrical impedance vector analysis (BIVA): a multi-site longitudinal cross-sectional mixed-methods study

Aghogho Odudu, University of Manchester, Oxygenation and perfusion imaging as a novel biomarker of disease progression in diabetic kidney disease

Rashmi Patel, King's College London, Symptom dimensions in first episode psychosis: predicting clinical outcomes using natural language processing

Gary Reynolds, Newcastle University, Genomic analysis of immune populations in giant cell arteritis

Aidan Rose, University of Dundee, Investigating Pro-oncogenic Activin Driven Proliferation and Clonagenicity in Human Cutaneous Squamous Cell Carcinoma

Alexander Rothman, University of Sheffield, Inhibition of SMURF1 for the treatment of pulmonary arterial hypertension

William Sedley, Newcastle University, Sensory precision in the causation and treatment of tinnitus

Maisa Seppala, King's College London, Odontomes as prognostic markers for disrupted WNT signalling

Markus Sikkel, Imperial College London, Enhancing the Therapeutic Index of Anti-arrhythmic Agents In Ischaemia through use of Hypoxia Activated Pro-drugs

Nicole Stoesser, University of Oxford, Genomic epidemiology of carbapenem resistance gene transmission amongst Enterobacteriacaeae in hospital drainage reservoirs

Peter Swoboda, University of Leeds, Assessment of the cardiovascular consequences of enforced abstinence from exercise

Rhys Thomas, Cardiff University, The neuronal glucose transporter in genetic generalised epilepsy

Naomi Walker, London School of Hygiene and Tropical Medicine, Matrix Degradation Products for TB diagnosis & prediction of TBImmune reconstitution inflammatory syndrome (IRIS)

Arash Yavari, University of Oxford, Defining the role of AMP-activated protein kinase signalling in the pathogenesis of atrial arrhythmia

Dr Sara Ajina, University of Oxford, Neural effects of rehabilitation following visual cortex damage

Dr Robert Aldridge, UCL, Public Health Informatics in the era of big data: estimating future burden of disease in England using electronic health records

Mr James Chan, University of Oxford, Upregulation of alarmins to accelerate fracture repair in normal and osteoporotic bone

Dr Andrew Douglas, University of Southampton, Therapeutic epigenetic manipulation of C9orf72 for amyotrophic lateral sclerosis and frontotemporal dementia

Dr Louis Grandjean, UCL, The Genomics of Multidrug-Resistant Tuberculosis Transmission

Dr Gordon Hutchins, University of Leeds, Towards an understanding of molecular heterogeneity in gastric cancer

Mr Farhad Iranpour Boroujeni, Imperial College London, Computer assisted patellofemoral joint surgery: Application of a novel technique for assessing dynamic patellar tracking and contact patterns in patellofemoral instability

Dr Kerri Jane Kinghorn, King's College London, Dissecting the mechanisms of pathogenesis of TBK1 mutations using ALS Drosophila models

Dr Helena Lee, University of Southampton, Oral Dopamine Replacement in the Developing Albino Retina - A Proof of Concept Study

Dr Stephen McAdoo, Imperial College London, Defining the role of SYK in the pathogenesis of experimental and clinical glomerulonephritis

Dr Roly Megaw, University of Edinburgh, In vivo correction of a human mutation in a mouse model of retinitis pigmentosa

Dr Christopher Moxon, University of Liverpool, Investigating sequestration driven pathology in cerebral malaria in vitro and post-mortem using transcriptomics

Dr Hani Nazzal, University of Leeds, Decellularisation of dental pulp for use as a scaffold in regenerative endodontics

Dr Elisabeth Rounis, University of Oxford, The neural correlates of affordance during grasp

Dr Adam Sharp, Institute of Cancer Research, Co-regulatory proteins of the androgen receptor and androgen receptor splice variants: A novel therapeutic strategy for the treatment of castration-resistant prostate cancer

Dr James Tomlinson, Imperial College London, Gene expression profiling of the proximal tubule in kidney fibrosis