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Professor Richard Marais FRS FMedSci

Job Title
Director & Professor of Molecular Oncology
Department
Cancer Research UK Manchester Institute
Institution
Cancer Research UK (CRUK)
Year elected
2008

Interests

Specialities

cell signalling, protein kinases, cancer (esp melanoma), therapeutics

Section committee elected by

Genetics, cellular and developmental biology, microbiology and immunology

Online Information

Lab Website

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Institute Website

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Richard Marais is Professor of Molecular Oncoloy at Cancer Research UK and has made important contributions to the understanding of cell signalling pathways, particularly in cancer. He was amongst the first to show that mitogen activated protein kinases regulate gene expression by directly phosphorylating transcription factors. However his greatest impact has been with the RAF kinase family, where he discovered that individual RAF proteins are regulated differentially and shown how they respond to RAS, which is mutated in a third of all human tumours. He was a key member of the team that demonstrated that B-RAF is encoded by an oncogene, which is a culprit in most human melanomas. He went on to validate B-RAF as a therapeutic target. In collaboration with David Barford, he solved the crystal structure of B-RAF and explained how it is activated by mutations that occur in cancer. He elucidated why C-RAF is not mutated in cancer, showing that mutant forms of B-RAF can activate C-RAF through a novel mechanism, establishing a new paradigm of RAF signaling. He is now translating these studies to the clinic by leading a large effort to design and synthesize new anti-B-RAF drugs that will be used to treat melanoma.

Anniversary Fellows Meeting 2018

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Joint symposium on mental health and addiction: A discussion, exchange and sharing of perspectives

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South-East Regional Annual Lecture 2018, Oxford, 3 December

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