Fellow

Back to directory listing

Professor David Rubinsztein FRS FMedSci

Job Title
Professor of Molecular Neurogenetics
Department
Cambridge Institute for Medical Research
Institution
University of Cambridge
Year elected
2004

Interests

Specialities

molecular pathogenesis of neurodegeneration, autophagy

Section committee elected by

Medical specialties (excluding oncology, neurology) and paediatrics

Online Information

Personal Website

Click here to view

David Rubinsztein’s is a Wellcome Trust Senior Clinical Fellow in Cambridge. His initial interests were in cholesterol metabolism, but he has made his major impact in neurodegenerative disorders caused by triplet repeat expansions, the paradigm for which is Huntington’s disease. During his clinical training period, David Rubinsztein contributed influential papers on the range of mutational sizes associated with disease, and on mutational bias, in relation to Huntington’s. Subsequently he has pursued the pathogenesis of neurodegeneration, by characterising cellular and biochemical abnormalities in diseases with CAG expansions. He set up novel model systems in cell culture, validated the behaviour of these models, and has produced a string of papers on the cellular effects of triplet expansions in Huntington’s and other diseases. His most recent work has taken the group forward from cell models, to screens for modifier loci in mice and to establishing mutants in zebra fish and rodents. The ingenious zebrafish models for screening potential therapeutic compounds he has developed in collaboration with Bill Harris and others constitute a major contribution to the field and hold the promise of clinical advance.

Anniversary Fellows Meeting 2018

Book Now

Joint symposium on mental health and addiction: A discussion, exchange and sharing of perspectives

Book Now

South-East Regional Annual Lecture 2018, Oxford, 3 December

Book Now
View more
 
 
 
 
 
 
FB Twitter Instagram Youtube