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Professor David Ron FRS FMedSci

Job Title
Professor of Cellular Pathophysiology and Clinical Biochemistry
Department
Clinical Biochemistry and IMS
Institution
University of Cambridge
Year elected
2013

Interests

Specialities

cell biology, biological chemistry, endocrinology, secretion, protein synthesis, unfolded protein response

Section committee elected by

Physics, chemistry, biochemistry, structural biology, mathematics, informatics and engineering applied to biomedicine

Online Information

Lab Website

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Institute Website

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David Ron is Professor of Cellular Pathophysiology and Clinical Biochemistry at the University of Cambridge. Protein misfolding in the endoplasmic reticulum (ER stress) is implicated in processes from neurodegeneration to endocrine disorders. David Ron has been at the forefront of this confluence of Cell Biology and Pathophysiology. He identified the transcription factor CHOP and discovered its role in deregulating adipose tissue development in liposarcoma. He identified the ER stress transducer PERK, establishing the molecular mechanism by which unfolded protein stress regulates protein synthesis and identified the long-sought mammalian counterpart of the yeast master regulator of gene expression in the UPR, IRE. An endocrinologist by training, he is deeply committed to disease-oriented research and laboratory practice.

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